Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity

Capsiate, a nonpungent capsaicin analogue, and its dihydroderivative dihydrocapsiate are the major capsaicinoids of thenonpungent red pepper cultivar CH-19 Sweet. In this study, we report the biological actions and underlying molecular mechanisms of capsiate on angiogenesis and vascular permeability. In vitro, capsiate and dihydrocapsiate inhibited vascularendothelial growth factor (VEGF)-induced proliferation, chemotactic motility, and capillary-like tube formation of primary cultured human endothelial cells.

 

Bo-Jeong Pyun, Sun Choi, Yoonji Lee, Tae-Woong Kim, Jeong-Ki Min, Yonghak Kim, Byung-Dong Kim, Jeong-Han Kim, Tae-Yoon Kim, Young-Myeong Kim, Young-Guen Kwon
January 1, 2008
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