A multi-national pharmaceutical company had developed a custom informatics system, providing all scientists in its discovery organization with access to essential research data. While information access was well-served by the tool, over time, a long list of new feature requests developed, as user needs grew and changed. Most notably, scientists needed access to new data sources and improved analysis capabilities, changes that would require extensive programming investment. Adding to the challenge, turnover in staff who developed the custom software was causing a loss of necessary expertise. A decision was reached. Software programming lay well outside the company’s core focus. Rather than invest further in the custom solution—duplicating work happening across the industry—the company would investigate the growing selection of off-the-shelf platforms for drug development informatics.