Enhanced, Shared Workflows for Clinical Pharmacology and Pharmacometrics

Customer-driven enhancements to the Certara Phoenix modeling platform saved time, enhanced collaboration, and improved access to high-performance computing for a diverse group of scientists.

A global pharmaceutical company was investigating data solutions to enhance capabilities of their clinical pharmacology and pharmacometrics (Pmx) groups. Their challenge: to provide enterprise-wide access to shared data, models, analyses, and reports for a diverse user base in a regulatory compliant manner, with direct integration of the scientists’ existing software tools.

The company sought a single platform that could support the varied and specialized workflows of their clinical pharmacology and Pmx scientists across the globe, while reducing time spent on data manipulation. The company’s clinical pharmacologists relied on Phoenix® WinNonlin® daily. Pharmacometricians performed population pharmacokinetic-pharmacodynamic (PKPD) modeling and simulation through NONMEM® supplemented with Perl Speaks NONMEM (PsN) modules, and statistical computing and graphics in the R language. Additional tools such as MATLAB® were also required.