The Certara Blog

What Does Clearance Mean?

What Does Clearance Mean?

Drug clearance is an extremely important topic in the science of pharmacokinetics. Drug clearance defines how much drug should be administered, how frequently to dose a patient, and how two interacting drugs will affect a patient. The primary PK parameter clearance is very similar to its friend, volume of distribution. Clearance (CL) is a proportionality […]

Read More
Understanding Volume of Distribution

Understanding Volume of Distribution

One of the most misunderstood pharmacokinetic (PK) parameters is volume of distribution. First of all it has numerous abbreviations (V, Vd, Vz, Vss, V1, Vc, V2, etc.), and to make matters worse, many people incorrectly define the parameter. But, once you understand the meaning behind volume of distribution, you will have a solid grasp on […]

Read More
What is Pharmacodynamics?

What is Pharmacodynamics?

Starting with definitions is always helpful… so after defining pharmacokinetics, a definition for pharmacodynamics is in order. The definition of pharmacodynamics (PD) is much less controversial than the definition for pharmacokinetics. The word pharmacodynamics is from two Greek words (see wikipedia for more): pharmakon: Drug dynamikós : force or power Thus, pharmacodynamics is the study […]

Read More
What is Pharmacokinetics?

What is Pharmacokinetics?

You might think this is a simple question, especially for an expert in pharmacokinetics. Well, this question is full of controversy with each scientist having their own opinion. I think this is because the definition of pharmacokinetics is simple, yet pharmacokinetics science is broad in scope. The word pharmacokinetics is from two greek words (see […]

Read More
Why Have a Blog About PK and PD?

Why Have a Blog About PK and PD?

Many blogs you will find on the internet are related to personal ventures, technology, or hobbies … all topics that are suited to the light-hearted fare that is common in the blogosphere. I believe that blogs can communicate knowledge in unique ways to a broad audience. Instead of developing a blog about my personal life, […]

Read More