Considering Age Variation when Coining Drugs as High vs Low Hepatic Extraction Ratio.

Hepatic extraction ratio (EH) is commonly considered as ‘an inherent attribute’ of drug. It determines the main physiological and biological elements of the system (patient attributes) which are most significant in inter-individual variability of clearance. EH consists of three age-dependent parameters: fraction of unbound drug in blood (fu.B), hepatic intrinsic clearance of unbound drug (,H) and hepatic blood flow (QH). When age-effects on these elements […]

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