Prediction of Vss from in vitro tissue binding studies.

To predict volume of distribution at steady-state (Vss), empirical (e.g., allometry) and mechanistic (using physicochemical property data and plasma protein binding) methods have been used. None of these approaches has been able to predict Vss accurately for the total compliment of a wide range of drugs. Therefore, alternative approaches would be of value. This study evaluates the […]

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