Application of IVIVE and PBPK modelling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies.

Prospective simulations of human pharmacokinetic (PK) parameters and plasma concentration-time curves using in vitro in vivo extrapolation (IVIVE) and physiologically based pharmacokinetic (PBPK) models are becoming a vital part of the drug discovery and development process. This paper presents a strategy to deliver prospective simulations in support of clinical candidate nomination. A three stage approach […]

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