Intravenous topiramate: Comparison of pharmacokinetics and safety with the oral formulation in healthy volunteers

Although oral¬†topiramate¬†(TPM) products are widely prescribed for migraines and epilepsy, injectable TPM is not available for human use. We have developed a solubilized TPM formulation using a cyclodextrin matrix, captisol with the long-term goal of evaluating its safety and efficacy in neonatal seizures. This study in healthy adult volunteers was performed as required by the […]

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