Modeling Delayed Outcomes in PK/PD Studies Using DDEs

Shuhua Hu

Delays are ubiquitous in pharmacokinetics (PK) and pharmacodynamics (PD) studies. Transit compartment models, described by systems of ordinary differential equations, have been widely used to describe delayed outcomes in PK and PD studies. The obvious disadvantage for this type of model is it requires manually finding proper values for the number of compartments. In addition, […]

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Topics: PK/PD Modeling & Simulation

A Distributed Delay Approach for Modeling Delayed Outcomes in Pharmacokinetics and Pharmacodynamics Studies

This poster demonstrates that the distributed delay approach is general enough to incorporate a wide array of models as special cases including transit compartment models, typical absorption models, and models for describing atypical absorption profiles such as double/multiple-peak phenomenon after oral administration in pharmacokinetics.

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