Automated Prediction of First-In-Man Dosing Using Pre-Clinical PK Data

Serge Guzy

If ever there was a cautionary tale illustrating the importance of getting allometric scaling of drugs right, it’s the story of Tusko the elephant. In 1962, Tusko was living at the Lincoln Park Zoo in Oklahoma City where he received a dose of the psychomimetic drug, lysergic acid diethylamide, better known as LSD. The dose […]

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Topics: PK/PD Modeling and Simulation
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