Simulation of Pharmacokinetics of Amitriptyline and Nortriptyline and Their Common Effect on Human Cardiac Electrophysiology in Healthy Population
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Authors: Sebastian Polak
Physiologically-based Pharmacokinetic Model (PBPK) for the Halofantrine Cardiac Effect Prediction – Proof of Concept Study towards the System for the Antimalarial Drugs Cardiac Safety Assessment
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Predicting Diclofenac Systemic and Synovial Fluid Concentrations After Dermal Application Using the Multi-phase Multi-layer MechDermA PBPK Model
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Commentary on “In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically-based Absorption Models”
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Early Assessment of Proarrhythmic Risk of Drugs Using the In Vitro Data and Single-cell-based In Silico Models: Proof of Concept
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Towards Development and Validation of the Dermal PBPK Model for Virtual Bioequivalence—Model Description and Validation Case Studies
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Towards mechanistic simulation and prediction of bioequivalence studies of topical formulations case study with two diclofenac formulations
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Simulating Cardiac Consequences of the Genetic Variability at the Metabolism Level With Use of Middle-Out Approach and Flecainide as an Example Compound
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Pharmacokinetic (PK) and Pharmacodynamic (PD) Implications of Diurnal Variation of Gastric Emptying and Small Intestinal Transit Time for Quinidine Mechanistic Simulation
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Prediction of the In Vivo Behaviour of Modified Release Formulations of Metoprolol from In Vitro Dissolution Profiles Using the ADAM Model (Simcyp® V8)
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Impact of Variability in Estimates of Drug Diffusion Coefficient on the Prediction of Fraction Absorbed from the Gut (fa) Using the ADAM Model (Simcyp v7.1)
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Mechanistic modeling of dermal drug absorption using the Simcyp Multi-phase Multi-layer MechDermA model: Case study of a transdermal patch formulation of weak base drug timolol
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Quantitative Prediction of Circadian Variation Impacts on Pharmacokinetics (PK): Dependence on Route of Administration in the Case of BCS/BDDCS Class II and CYP3A4 Substrate Drug Nifedipine
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Mechanistic Models of Human Pharmacokinetics to Predict the Effects of Liver Cirrhosis on the Clearance of Nine Drugs
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Mechanistic Models of Human Pharmacokinetics to Predict the Effects of Liver Cirrhosis on the Clearance of Nine Drugs
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Population level simulation of the action potential as a system for the drugs pro-arrhythmic potency classification
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Simulating pharmacokinetic and pharmacodynamic impact of the drug formulation on the human cardiac safety by applying in vitro – in vivo extrapolation approach
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Prediction of skin disposition after topical application of drugs Simcyp platform as a tool for capturing system information and safety assessment
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Combining In Vitro-In Vivo Extrapolation (IVIVE) and Physiologically-based Pharmacokinetics (PBPK) with Drug Related Risk Assessment: Putting Pieces Together for A Priori Assessment of the Likelihood of Cardiotoxicity
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Prediction of Human Pharmacokinetics Following Dermal Administration: Integration of a Skin Absorption Module to the Simcyp® Population-based ADME Simulator with the Aim of Avoiding Animal Studies
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