Development of a Permeability-Limited Cardiac Physiologically-Based Pharmacokinetic Model for Predicting Cardiac Exposure
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Authors: Sebastian Polak
The Certara Quantitative Systems Toxicology & Safety (QSTS) Pharma Consortium: Overview and Invitation to Join
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Development of a PBPK model for topical lidocaine in order to predict systemic absorption in healthy volunteers, geriatrics and paediatrics
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Quantitative description of the physiological changes in diseased skin and their incorporation into Physiologically Based Pharmacokinetic Models.
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Predicting Diffusion in the Dermis: a Physiologically Based, Bottom-up Approach
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Modeling in vitro skin permeation experiments to mechanistically understand in vivo dermal absorption: Application of in vitro-in vivo extrapolation (IVIVE) and physiological based pharmacokinetic (PBPK) modeling using testosterone as model drug
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Development of the dermal absorption model for the ketoprofen local and systemic exposure prediction
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Assessing Formulation Attributes’ Impact On Local And Systemic Exposure Of Clindamycin After Topical Application Of Pro-Drug Clindamycin Phosphate Using PBPK Modelling
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Mechanistic Physiologically-Based Pharmacokinetic Modelling for Prediction of Dermal Absorption in Psoriatic Patients
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Predicting local tissue concentrations after topical drug application with a physiologically-based pharmacokinetic model
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Towards Virtual Exposure Assessment of Dermally Applied Drugs – PBPK Model of Buprenorphine Transdermal Patches
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Integration of physicochemical product characteristics within a mechanistic dermal PBPK model to support virtual bioequivalence evaluation of topical drug products: A case study with acyclovir topical creams
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Effect of Multiple Drugs Interacting with the hERG Channel – In Vitro Study
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In silico assessment of nifedipine effects on human heart cells: pharmacokinetic-pharmacodynamic analyses at the population level
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Simulating the effect of anti-diabetic drugs on ATP-sensitive potassium (KATP) channels inhibition in a human cardiac cell model (ORd)
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An in silico PBPK-PD coupled approach to assess Zolpidem effect on pre-clinically and clinically measured cardiac repolarisation parameters in the absence and presence of a circadian model of plasma ion concentration.
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Repolarisation Rate: an integrative biomarker of cardiac action potential repolarisation
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Towards unravelling the mechanism of Cardiotoxicity of Citalopram: Utilisation of mechanistic cardiac electrophysiology modelling with Simcyp Cardiac Safety Simulator to explore various hypotheses
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Mechanistic modelling of dermal drug absorption using the Simcyp Multi-phase Multi-layer MechDermA model: Case study of a transdermal patch formulation of weak base drug timolol
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Toward Unravelling the Mechanism of Cardiotoxicity of Citalopram: Utilization of Mechanistic Cardiac Electrophysiology Modelling with Simcyp Cardiac Safety Simulator (CSS) to Explore Various Hypotheses
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