Quantitative Prediction of Dermal Drug Absorption Using MPML-MechDermA Model: Relative Effects of Application Site on Rivastigmine Pharmacokinetics from a Transdermal Delivery System
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Authors: Sebastian Polak
Development and Verification of PBPK Model for a Topical Cream Formulation of Trifarotene to Simulate Local and Systemic Exposure and Model Application to Simulate Potential CYP-mediated Drug-drug Interactions
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Development and Validation of a Dermal PBPK Model for Prediction of the Hair Follicular Absorption of Caffeine: Application of the Simcyp MechDermA Model
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Multi-phase Multi-layer MechDermA Model: Development, Verification and Application of a PBPK/PD Model of Dermal Absorption for Transdermal Product Assessment
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Simulation of Pharmacokinetics of Amitriptyline and Nortriptyline and Their Common Effect on Human Cardiac Electrophysiology in Healthy Population
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Physiologically-based Pharmacokinetic Model (PBPK) for the Halofantrine Cardiac Effect Prediction – Proof of Concept Study towards the System for the Antimalarial Drugs Cardiac Safety Assessment
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Predicting Diclofenac Systemic and Synovial Fluid Concentrations After Dermal Application Using the Multi-phase Multi-layer MechDermA PBPK Model
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Commentary on “In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically-based Absorption Models”
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Early Assessment of Proarrhythmic Risk of Drugs Using the In Vitro Data and Single-cell-based In Silico Models: Proof of Concept
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Real Patients & Their Virtual Twins: A New Paradigm for Personalized Drug Safety Assessment
June 19, 2018 – In this webinar, Sebastian Polak, Nikunj Patel, and Mark Holbrook will introduce the Cardiac Safety Simulator (CSS) platform and explain how they developed a QSTS model for citalopram to serve as a “virtual twin” and help predict the likely occurrence of cardiotoxic events in real patients under different clinical conditions.
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Towards Development and Validation of the Dermal PBPK Model for Virtual Bioequivalence—Model Description and Validation Case Studies
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Towards mechanistic simulation and prediction of bioequivalence studies of topical formulations case study with two diclofenac formulations
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Simulating Cardiac Consequences of the Genetic Variability at the Metabolism Level With Use of Middle-Out Approach and Flecainide as an Example Compound
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Pharmacokinetic (PK) and Pharmacodynamic (PD) Implications of Diurnal Variation of Gastric Emptying and Small Intestinal Transit Time for Quinidine Mechanistic Simulation
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Prediction of the In Vivo Behaviour of Modified Release Formulations of Metoprolol from In Vitro Dissolution Profiles Using the ADAM Model (Simcyp® V8)
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Impact of Variability in Estimates of Drug Diffusion Coefficient on the Prediction of Fraction Absorbed from the Gut (fa) Using the ADAM Model (Simcyp v7.1)
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Mechanistic modeling of dermal drug absorption using the Simcyp Multi-phase Multi-layer MechDermA model: Case study of a transdermal patch formulation of weak base drug timolol
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Quantitative Prediction of Circadian Variation Impacts on Pharmacokinetics (PK): Dependence on Route of Administration in the Case of BCS/BDDCS Class II and CYP3A4 Substrate Drug Nifedipine
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Mechanistic Models of Human Pharmacokinetics to Predict the Effects of Liver Cirrhosis on the Clearance of Nine Drugs
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Mechanistic Models of Human Pharmacokinetics to Predict the Effects of Liver Cirrhosis on the Clearance of Nine Drugs
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