Development of a PBPK model for topical lidocaine in order to predict systemic absorption in healthy volunteers, geriatrics and paediatrics
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Authors: Sebastian Polak
Quantitative description of the physiological changes in diseased skin and their incorporation into Physiologically Based Pharmacokinetic Models.
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Repolarisation Rate: an integrative biomarker of cardiac action potential repolarisation
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Towards unravelling the mechanism of Cardiotoxicity of Citalopram: Utilisation of mechanistic cardiac electrophysiology modelling with Simcyp Cardiac Safety Simulator to explore various hypotheses
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Mechanistic modelling of dermal drug absorption using the Simcyp Multi-phase Multi-layer MechDermA model: Case study of a transdermal patch formulation of weak base drug timolol
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Toward Unravelling the Mechanism of Cardiotoxicity of Citalopram: Utilization of Mechanistic Cardiac Electrophysiology Modelling with Simcyp Cardiac Safety Simulator (CSS) to Explore Various Hypotheses
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Simulating the effect of anti-diabetic drugs on ATP-sensitive potassium (KATP) channels inhibition in a human cardiac cell model (ORd)
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Development of a Physiologically-Based Pharmacokinetic Model for Topical Lidocaine in Order to Predict Systemic Absorption in Healthy Volunteers, Geriatrics, and Pediatrics
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