CYP2E1 substrate inhibition. Mechanistic interpretation through an effector site for monocyclic compounds

In this study we offer a mechanistic interpretation of the previously known but unexplained substrate inhibition observed for CYP2E1. At low substrate concentrations, p-nitrophenol (pNP) was rapidly turned over (47 min-1) with relatively low Km (24 µM); nevertheless, at concentrations of >100 µM, the rate of pNP oxidation gradually decreased as a second molecule bound […]

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