Mechanistic Toxicokinetic Model for γ-Hydroxybutyric Acid: Inhibition of Active Renal Reabsorption as a Potential Therapeutic Strategy

γ-Hydroxybutyric acid (GHB), a drug of abuse, exhibits saturable renal clearance  and capacity-limited  metabolism.   The  objectives  of  this  study  were  to  construct  a  mechanistic  toxicokinetic  (TK) model  describing  saturable renal  reabsorption and  capacity-limited  metabolism  of GHB  and  to predict the  effects  of  inhibition   of  renal   reabsorption  on  GHB   TK  in  the  plasma  and  urine.   GHB   was administered by […]

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