The determination of drug metabolising enzyme activity in vivo: pharmacokinetics and statistical issues.

Probe substrates for various isoforms of cytochrome P450 and other drug-metabolizing enzymes are now widely used to assess genetic, environmental and ethnic differences in the in vivo metabolism of drugs and other xenobiotics .The key issues in assessing drug-metabolizing enzyme activity in vivo include separation (with the aid of genotyping) of risk and exposure; choice […]

Read More
Learn More