Predicting Human Oral Bioavailability: Comparison of In Vivo Animal (Rat- Dog- and Monkey) Studies versus Mechanistic In Vitro In Vivo Extrapolation (IVIVE) Based Predictions
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Authors: Nikunjkumar Patel
Predicting Human Oral Bioavailability: Comparison of in vivo animal (rat, dog, and monkey) studies versus mechanistic in vitro in vivo extrapolation (IVIVE) based predictions
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Development of a PBPK model for topical lidocaine in order to predict systemic absorption in healthy volunteers, geriatrics and paediatrics
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Quantitative description of the physiological changes in diseased skin and their incorporation into Physiologically Based Pharmacokinetic Models.
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Predicting Diffusion in the Dermis: a Physiologically Based, Bottom-up Approach
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Modeling in vitro skin permeation experiments to mechanistically understand in vivo dermal absorption: Application of in vitro-in vivo extrapolation (IVIVE) and physiological based pharmacokinetic (PBPK) modeling using testosterone as model drug
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Development of the dermal absorption model for the ketoprofen local and systemic exposure prediction
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Assessing Formulation Attributes’ Impact On Local And Systemic Exposure Of Clindamycin After Topical Application Of Pro-Drug Clindamycin Phosphate Using PBPK Modelling
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Mechanistic Physiologically-Based Pharmacokinetic Modelling for Prediction of Dermal Absorption in Psoriatic Patients
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Predicting local tissue concentrations after topical drug application with a physiologically-based pharmacokinetic model
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Towards Virtual Exposure Assessment of Dermally Applied Drugs – PBPK Model of Buprenorphine Transdermal Patches
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Integration of physicochemical product characteristics within a mechanistic dermal PBPK model to support virtual bioequivalence evaluation of topical drug products: A case study with acyclovir topical creams
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Physiologically-Based Pharmacokinetic (PBPK) Modelling Approach for the Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs – A Simulation Study of Posaconazole Using the Simcyp ADAM Model
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Mechanistic Model-Based Analysis of Biopharmaceutics Experiments- Application of In Vitro in Vivo Extrapolation (IVIV_E) Techniques Within A PBPK Modelling Framework
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Towards unravelling the mechanism of Cardiotoxicity of Citalopram: Utilisation of mechanistic cardiac electrophysiology modelling with Simcyp Cardiac Safety Simulator to explore various hypotheses
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Mechanistic modelling of dermal drug absorption using the Simcyp Multi-phase Multi-layer MechDermA model: Case study of a transdermal patch formulation of weak base drug timolol
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Toward Unravelling the Mechanism of Cardiotoxicity of Citalopram: Utilization of Mechanistic Cardiac Electrophysiology Modelling with Simcyp Cardiac Safety Simulator (CSS) to Explore Various Hypotheses
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APPLICATION OF A MULTI-COMPARTMENT PERMEABILITY-LIMITED LUNG MODEL TO PREDICT LUNG CONCENTRATIONS OF MOXIFLOXACIN IN VIRTUAL HUMAN SUBJECTS
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Establishing an In Vitro-In Vivo Correlation (IVIVC) for Tramadol Extended-Release Tablets : Conventional vs. Physiologically Based IVIVC
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Development of a Physiologically-Based Pharmacokinetic Model for Topical Lidocaine in Order to Predict Systemic Absorption in Healthy Volunteers, Geriatrics, and Pediatrics
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