Nikunjkumar Patel

Combining Machine Learning and Mechanistic Modeling Approaches to Solve Real Life Problems and Assessment of the Local Tissue Binding and Its Influence on the Systemic Exposure after Topical Application of Drugs

0 comments. Click here to read/write comments.

Topics:

Performance Verification of Mechanistic Dermal Physiological Based Pharmacokinetic (PBPK) Model for Enhanced Understanding of Dermal Absorption: Prediction of Local Tissue Exposure after Topical Application of Acitretin

0 comments. Click here to read/write comments.

Topics:

Real Patients & Their Virtual Twins: A New Paradigm for Personalized Drug Safety Assessment

In this webinar, Sebastian Polak, Nikunj Patel, and Mark Holbrook introduced the Cardiac Safety Simulator (CSS) platform and explained how they developed a QSTS model for citalopram to serve as a “virtual twin” and help predict the likely occurrence of cardiotoxic events in real patients under different clinical conditions.

0 comments. Click here to read/write comments.

Topics:

Skin in the Game: Mechanistic Modeling of Dermal Drug Absorption

Posted by Nikunjkumar Patel

on Mar 2, 2018 8:32:22 AM

The ability to estimate systemic exposure from dermal absorption is essential in developing new dermatological medications or assessing the toxicological liability of commercially-used chemicals. Historically, animal models were used to evaluate dermal drug absorption prior to clinical testing. However, both differences in human and animal physiology as well as ethical concerns over animal testing have […]

0 comments. Click here to read/write comments.

Topics: PBPK Modeling & Simulation

What’s New in the Simcyp Simulator v17?

Watch this webinar with Nikunjkumar Patel, Oliver Hatley, and Matthew Harwood to learn how the latest updates in the Simcyp Simulator v17 will help provide insights that support developing safer, more effective medications.

0 comments. Click here to read/write comments.

Topics:

Quantitative Prediction of Dermal Drug Absorption Using MPML-MechDermA Model: Relative Effects of Application Site on Rivastigmine Pharmacokinetics from a Transdermal Delivery System

0 comments. Click here to read/write comments.

Topics:

Development and Verification of PBPK Model for a Topical Cream Formulation of Trifarotene to Simulate Local and Systemic Exposure and Model Application to Simulate Potential CYP-mediated Drug-drug Interactions

0 comments. Click here to read/write comments.

Topics:

Development and Validation of a Dermal PBPK Model for Prediction of the Hair Follicular Absorption of Caffeine: Application of the Simcyp MechDermA Model

0 comments. Click here to read/write comments.

Topics:

Multi-phase Multi-layer MechDermA Model: Development, Verification and Application of a PBPK-PD Model of Dermal Absorption for Transdermal Product Assessment

0 comments. Click here to read/write comments.

Topics:

Multi-phase Multi-layer MechDermA Model: Development, Verification and Application of a PBPK/PD Model of Dermal Absorption for Transdermal Product Assessment

0 comments. Click here to read/write comments.

Topics:

Development and Validation of a Dermal PBPK Model for Prediction of the Hair Follicular Absorption of Caffeine: Application of the Simcyp MPML MechDermA Model

0 comments. Click here to read/write comments.

Topics:

Predicting Diclofenac Systemic and Synovial Fluid Concentrations After Dermal Application Using the Multi-phase Multi-layer MechDermA PBPK Model

0 comments. Click here to read/write comments.

Topics:

Modeling & Simulation for Drug Development & Formulation

A look at how to leverage modeling and simulation technology to enhance all phases of the drug development process.

0 comments. Click here to read/write comments.

Topics:

Commentary on “In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically-based Absorption Models”

0 comments. Click here to read/write comments.

Topics:

Early Assessment of Proarrhythmic Risk of Drugs Using the In Vitro Data and Single-cell-based In Silico Models: Proof of Concept

0 comments. Click here to read/write comments.

Topics:

Mechanistic Dissolution, Supersaturation and Precipitation Models to Simulate Simultaneous Dissolution of Two Solid State Mixtures of Ritonavir

0 comments. Click here to read/write comments.

Topics:

Physiologically-based Pharmacokinetic (PBPK) Modeling Approach for the Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs—A Simulation Study of Posaconazole Using the Simcyp ADAM Model

Weakly basic poorly soluble drug compounds, such as posaconazole (POSA), may dissolve completely at fasted gastric pH but precipitate upon transit to higher small intestinal pH. A number of in vitro and in vivo methods have been used to study intestinal precipitation of poorly soluble drug compounds with a varying degree of complexity. This research […]

0 comments. Click here to read/write comments.

Topics:

Mechanistic Modeling Using Classical Nucleation Theory of Fluid Dynamics and Dissolution Media Effects on Supersaturation and Precipitation Behavior Based upon a USP 2 Style Transfer Apparatus: A Simulation Exercise

0 comments. Click here to read/write comments.

Topics:

Mechanistic Model-based Analysis of Biopharmaceutics Experiments—Application of In Vitro-In Vivo Extrapolation (IVIVE) Techniques within a PBPK Modeling Framework

In vitro dissolution testing is a critical component of drug product development and is often used as a surrogate for in vivo performance. While the range of (USP) standard methods have been developed and tested for many years, no single dissolution test or apparatus comprehensively maps the in vivo behaviour of the range of compound […]

0 comments. Click here to read/write comments.

Topics:

Development and Validation of Dermal PBPK Model Towards Virtual Bioequivalence Assessment: Prediction of Dermal Drug Absorption of Various Ibuprofen Formulations Using Simcyp MechDermA Model

0 comments. Click here to read/write comments.

Topics: