Predicting Human Oral Bioavailability: Comparison of in vivo animal (rat, dog, and monkey) studies versus mechanistic in vitro in vivo extrapolation (IVIVE) based predictions
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Authors: Nikunjkumar Patel
Development of a PBPK model for topical lidocaine in order to predict systemic absorption in healthy volunteers, geriatrics and paediatrics
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Quantitative description of the physiological changes in diseased skin and their incorporation into Physiologically Based Pharmacokinetic Models.
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Predicting Diffusion in the Dermis: a Physiologically Based, Bottom-up Approach
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Modeling in vitro skin permeation experiments to mechanistically understand in vivo dermal absorption: Application of in vitro-in vivo extrapolation (IVIVE) and physiological based pharmacokinetic (PBPK) modeling using testosterone as model drug
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Development of the dermal absorption model for the ketoprofen local and systemic exposure prediction
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Assessing Formulation Attributes’ Impact On Local And Systemic Exposure Of Clindamycin After Topical Application Of Pro-Drug Clindamycin Phosphate Using PBPK Modelling
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Mechanistic Physiologically-Based Pharmacokinetic Modelling for Prediction of Dermal Absorption in Psoriatic Patients
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Predicting local tissue concentrations after topical drug application with a physiologically-based pharmacokinetic model
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Towards Virtual Exposure Assessment of Dermally Applied Drugs – PBPK Model of Buprenorphine Transdermal Patches
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Integration of physicochemical product characteristics within a mechanistic dermal PBPK model to support virtual bioequivalence evaluation of topical drug products: A case study with acyclovir topical creams
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Physiologically-Based Pharmacokinetic (PBPK) Modelling Approach for the Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs – A Simulation Study of Posaconazole Using the Simcyp ADAM Model
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Mechanistic Model-Based Analysis of Biopharmaceutics Experiments- Application of In Vitro in Vivo Extrapolation (IVIV_E) Techniques Within A PBPK Modelling Framework
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Towards unravelling the mechanism of Cardiotoxicity of Citalopram: Utilisation of mechanistic cardiac electrophysiology modelling with Simcyp Cardiac Safety Simulator to explore various hypotheses
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Mechanistic modelling of dermal drug absorption using the Simcyp Multi-phase Multi-layer MechDermA model: Case study of a transdermal patch formulation of weak base drug timolol
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Toward Unravelling the Mechanism of Cardiotoxicity of Citalopram: Utilization of Mechanistic Cardiac Electrophysiology Modelling with Simcyp Cardiac Safety Simulator (CSS) to Explore Various Hypotheses
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APPLICATION OF A MULTI-COMPARTMENT PERMEABILITY-LIMITED LUNG MODEL TO PREDICT LUNG CONCENTRATIONS OF MOXIFLOXACIN IN VIRTUAL HUMAN SUBJECTS
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Establishing an In Vitro-In Vivo Correlation (IVIVC) for Tramadol Extended-Release Tablets : Conventional vs. Physiologically Based IVIVC
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Development of a Physiologically-Based Pharmacokinetic Model for Topical Lidocaine in Order to Predict Systemic Absorption in Healthy Volunteers, Geriatrics, and Pediatrics
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What’s New in the Simcyp Simulator v18?
Watch this webinar with Nikunjkumar Patel, Shriram Pathak, and Rachel Rose to learn how the latest updates in the Simcyp Simulator v18 will help support developing safer, more effective medications.
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