Application of CYP3A4 in vitro data to predict clinical drug-drug interactions: predictions of compounds as objects of interaction.

Numerous retrospective analyses have shown the utility of in vitro systems for predicting potential drug-drug interactions (DDIs). Prediction of DDIs from in vitro data is commonly obtained using estimates of enzyme KI, inhibitor and substrate concentrations and absorption rate for substrate and inhibitor. Using a generic approach for all test compounds, the findings from the current study showed the use of recombinant P450s provide […]

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