Prediction of metabolic drug clearance in humans: in vitro-in vivo extrapolation vs allometric scaling

Previously in vitro-in vivo extrapolation (IVIVE) with the Simcyp Clearance and Interaction SimulatorĀ® has been used to predict the clearance of 15 clinically used drugs in humans. The criteria for the selection of the drugs were that they are used as probes for the activity of specific cytochromes P450 (CYPs) or have a single CYP […]

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