Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.

The maintenance dose of a drug is dependent on drug clearance, and thus any biochemical and physiological changes in obesity that affect parameters such as cardiac output, renal function, expression of drug-metabolizing enzymes and protein binding may result in altered clearance compared with that observed in normal-weight subjects (corrected or uncorrected for body weight). Because […]

Read More
Learn More