Application of Global Sensitivity Analysis Methods to Determine the Most Influential Parameters of a Minimal PBPK Model of Quinidine
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Authors: Linzhong Li
A Whole Body Physiologically-based Pharmacokinetic Model for Antibody Drug Conjugates—Model Development and Validation in Rat
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Mechanistic Modeling of Antibody Drug Conjugate Pharmacokinetics
Antibody Drug Conjugates (ADCs) are constructed by attaching a small molecule drug to an antibody via a linker. The antibody selectively targets tumor cells and releases the cytotoxic drug within the cells to kill cancerous cells while sparing healthy tissue. Although some ADCs have been approved, many unanswered questions remain, such as drug-drug interactions (DDIs) and […]
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PBPK Modeling & SimulationA Bottom-up Whole-body Physiologically-based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins
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A Mechanistic Minimal PBPK Model to Predict Distribution and Subcutaneous Absorption of Therapeutic Proteins
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A Minimal Physiologically-based Pharmacokinetic Model of IgG: Impact of Inclusion of 2:1 FcRn IgG Binding Stoichiometry and a Proportion of CL That Is Independent of FcRn Binding
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Emerging Covariates on the Pharmacokinetics of Monoclonal Antibodies: Do Current PBPK Models Account for the Significant Covariates Identified in PopPK Studies?
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Prediction of the Pharmacokinetics, Pharmacodynamics, and Efficacy of a Monoclonal Antibody, Using a Physiologically-based Pharmacokinetic FcRn Model
Although advantages of physiologically based pharmacokinetic models (PBPK) are now well established, PBPK models that are linked to pharmacodynamic (PD) models to predict pharmacokinetics (PK), PD, and efficacy of monoclonal antibodies (mAbs) in humans are uncommon. The aim of this study was to develop a PD model that could be linked to a physiologically based mechanistic FcRn model to predict PK, PD, and efficacy of efalizumab. The mechanistic FcRn model for mAbs with target-mediated drug disposition within […]
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A Mechanistic PBPK Model to Predict Subcutaneous Absorption of Therapeutic Proteins and Monoclonal Antibodies
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Modeling the Binding Kinetics of Antibody, Antigen, and FcyRs
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Simulation of Monoclonal Antibody Pharmacokinetics in Humans Using a Minimal Physiologically-based Model
Compared to small chemical molecules, antibodies and Fc-containing derivatives (mAbs) have unique pharmacokinetic behavior characterized by relatively poor cellular permeability, minimal renal filtration, binding to FcRn, target-mediated drug disposition, and disposition via lymph. A minimal physiologically based pharmacokinetic (PBPK) model to describe the pharmacokinetics of mAbs in humans was developed. Within the model, the body is divided into three physiological compartments; plasma, a single tissue compartment and lymph. The […]
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Exploring Fixed Dose versus Body Weight-based Dosing for Monoclonal Antibodies Using Physiologically-based Pharmacokinetic Modeling
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A Mechanistic Model to Predict Subcutaneous Absorption of Therapeutic Proteins Linked to a Whole Body PBPK Model
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A Semi-mechanistic Model to Predict Renal Clearance of Therapeutic Proteins Linked to a Whole Body PBPK Model
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Modeling the Binding Kinetics of Bispecific Antibodies under the Framework of a Minimal Human PBPK Model
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Incorporating Target Shedding into a Minimal PBPK-TMDD Model for Monoclonal Antibodies
Shedding of a pharmacological target from cells, giving rise to a soluble target that can also bind therapeutic proteins, is a common phenomenon. In this study, a minimal physiologically based pharmacokinetic model was used to simulate the pharmacokinetics of trastuzumab and the simultaneous binding of the compound to soluble (in blood and tissue interstitial space) and membrane-bound (in the tissue interstitial space) forms of […]
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Use of a Minimal PBPK Model to Investigate the Effect of Shed Antigen on Simulated Trastuzumab in Humans
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A Whole Body PBPK Model to Predict Plasma and Tissue Interstitial Fluid Concentrations in Humans for Proteins with a Range of Sizes
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Extending TMDD Models to Simulate the PK of mAbs that Bind to Both a Cell Surface Antigen on Leukocytes and Shed Antigen in the Circulation
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Accounting for Transporters in Renal Clearance: Towards a Mechanistic Kidney Model (Mech KiM)
The impact of transporters in modulating the disposition of drugs in the liver and their passage across the gut wall has received much more attention than their role in renal excretion, despite the fact that 25–30 % of drugs are cleared predominantly by renal clearance and renal transporters contribute significantly to this process. Thus there […]
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