Application of Global Sensitivity Analysis Methods to Determine the Most Influential Parameters of a Minimal PBPK Model of Quinidine
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Authors: Linzhong Li
A Whole Body Physiologically-based Pharmacokinetic Model for Antibody Drug Conjugates – Model Development and Validation in Rat
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A Whole Body PBPK Model to Predict Plasma and Tissue Interstitial Fluid Concentrations in Humans for Proteins with a Range of Sizes
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A Minimal Physiologically-based Pharmacokinetic Model of IgG: Impact of Inclusion of 2:1 FcRn IgG Binding Stoichiometry and a Proportion of CL That is independent of FcRn Binding
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Modeling the Binding Kinetics of Bispecific Antibodies under the Framework of a Minimal Human PBPK Model
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Extending TMDD Models to Simulate the PK of mAbs that Bind to Both a Cell Surface Antigen on Leukocytes and Shed Antigen in the Circulation
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A mechanistic minimal PBPK model to predict distribution and subcutaneous absorption of therapeutic proteins
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Emerging Covariates on the Pharmacokinetics of Monoclonal Antibodies: Do Current PBPK Models Account for the Significant Covariates Identified in POPPK Studies?
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Modeling the Binding Kinetics of Antibody, Antigen and Fc?Rs
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Incorporating target shedding into a minimal PBPK-TMDD model for mAbs
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Use of a minimal PBPK model to investigate the effect of shed antigen on simulated Trastuzumab in humans
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The effect of IgG-FcRn binding stoichiometry on simulated mAb half-life using a minimal human PBPK model
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Development of a Minimal-PBPK Model for Simulating Monoclonal Antibody Pharmacokinetics in Human
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A mechanistic PBPK model to predict subcutaneous absorption of therapeutic proteins and monoclonal antibodies
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A mechanistic model to predict subcutaneous absorption of therapeutic proteins linked to a whole body PBPK model
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A semi-mechanistic model to predict renal clearance of therapeutic proteins linked to a whole body PBPK model
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Exploring fixed dose versus body weight based dosing for monoclonal antibodies using physiologically-based pharmacokinetic modeling
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An assessment of the OCT2/MATE transporter mediated interaction between metformin and cimetidine using a mechanistic kidney model (Mech KiM)
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Mechanistic Modeling of Antibody Drug Conjugate Pharmacokinetics
Antibody Drug Conjugates (ADCs) are constructed by attaching a small molecule drug to an antibody via a linker. The antibody selectively targets tumor cells and releases the cytotoxic drug within the cells to kill cancerous cells while sparing healthy tissue. Although some ADCs have been approved, many unanswered questions remain, such as drug-drug interactions (DDIs) and […]
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Drug Safety, Model-based Drug Development, PBPK Modeling and SimulationA Bottom-Up Whole-Body Physiologically Based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins
The ability to predict subcutaneous (SC) absorption rate and tissue distribution of therapeutic proteins (TPs) using a bottom-up approach is highly desirable early in the drug development process prior to clinical data being available. A whole-body physiologically based pharmacokinetic (PBPK) model, requiring only a few drug parameters, to predict plasma and interstitial fluid concentrations of […]
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