In vitro inhibition of multiple cytochrome P450 isoforms by xanthone derivatives from mangosteen extract.

Mangosteen is a xanthone-containing fruit found in Southeast Asia for which health claims include maintaining healthy immune and gastrointestinal systems to slowing the progression of tumor growth and neurodegenerative diseases. Previous studies have identified multiple xanthones in the pericarp of the mangosteen fruit. The aim of the current study was to assess the drug inhibition potential of mangosteen in vitro as well as thecytochrome P450 (P450) enzymes responsible for […]

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