Development and Performance Evaluation of a semi-mechanistic PBPK Model for Topical Ocular Delivery of Pilocarpine and Timolol to Rabbit Eye
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Authors: Iain Gardner
Development of Paclitaxel PBPK Model to Predict Tumour Concentration in Cancer Patients
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Integration of a Tumour Growth Inhibition Model within a Mouse Physiologically-Based Pharmacokinetic Model
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Development of a PBPK Model for Docetaxel as a CYP3A Substrate and Accounting for Binding to Multiple Plasma Proteins
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Certara’s Best of the Blog 2017
A selection of short essays from our blog, written to empower our customers with modeling and simulation (M&S) and regulatory writing solutions in order to help them solve the toughest drug development problems. Certara staff contributions range in topic from pharmacometrics to systems biology to the growing importance of regulatory writing and sharing clinical trial results.
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Physiologically-based Pharmacokinetic (PBPK) Modeling to Explore the Potential Role of Cytochrome P450 3A Enzyme in Colonic Drug Metabolism—Oxybutynin: A Case Study
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Use of a PBPK Modeling Approach to Predict the In Vivo Clearance of Aldehyde Oxidase Substrates
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Evaluation of In Vitro-In Vivo Extrapolation (IVIVE) of the Induction Potential for Known CYP 2C9 Inducers
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Abundance & Relative Segmental Expression of Intestinal Transporters in Caucasians: A Meta-analysis
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In Vitro-In Vivo Extrapolation of Intestinal Transporter Activity Using an Absolute Transporter Abundance Approach Within a PBPK Framework
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Version Comparison and Performance Verification of Library Compounds Within the Simcyp Simulator
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Performance Verification of v17 Sim-cancer Population in Simcyp
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Evaluation of In Vitro-In Vivo Extrapolation (IVIVE) of the Induction Potential for Known CYP2C9 Inducers
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A Whole Body Physiologically-based Pharmacokinetic Model for Antibody Drug Conjugates—Model Development and Validation in Rat
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New Tools Support Developing Better TB Drugs
Tuberculosis (TB)—caused by infection with the mycobacterium Mycobacterium tuberculosis—is one of the top 10 leading causes of death worldwide with a total of 1.8 million people dying from the disease in 2015. TB is also the leading cause of death in HIV-infected individuals. TB usually attacks the lungs but can infect any part of the […]
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PBPK Modeling & SimulationExtension of Simcyp Brain Model for Proteins to Investigate Transferrin Receptor Transport
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Prediction of Large Molecule Clearance in Children Using Allometry vs. PBPK—Erythropoietin as a Case Example
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Extension of Simcyp Brain Model for Proteins to Investigate Transferrin Receptor Transport
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A Multi-compartment Liver Model for the Prediction of Toxicokinetics
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PBPK Modeling of Target Organ Concentrations for Reverse Dosimetry
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