Development of a PBPK model for the prediction of Amiodarone pharmacokinetics in fed and fasted state using the Advanced Dissolution, Absorption and Metabolism (ADAM) model
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Authors: Iain Gardner
Dosing corrected for species differences in toxicokinetics using PBPK modelling predicts equivalent reactive metabolite burden following acetaminophen overdose
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Development of a PBPK model for the prediction of Amiodarone pharmacokinetics in fed and fasted state using ADAM model
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Prediction of mAb disposition in hepatic impairment – Evolocumab as a case study
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Biopharmaceutic In Vitro In Vivo Extrapolation (IVIV_E) Informed PBPK Model of Ritonavir Norvir® Tablet Absorption in Humans Under Fasted and Fed State Conditions
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Accounting for CYP2C19 mechanism based inhibition and CYP1A2 induction in a PBPK model for omeprazole
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Performance Verification and Application of a Cancer population for use in Physiologically Based Pharmacokinetic modelling
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Biokinetic and PBPK modelling to support the rotenone and strobilurin read across case studies (CS4)
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Biokinetic and PBPK Modelling to Support Read-Across Assessment of Repeat Dose and Developmental and Reproductive Toxicity of Valproic Acid Analogues
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Physiologically Based Pharmacokinetic/Pharmacodynamic model of gastrointestinal toxicity induced by 5-fluorouracil in mouse and translation to human
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Development of a Physiologically Based Pharmacokinetic Model of Buspirone and Its Active Metabolite 1-(2-Pyrimidinyl)-Piperazine to Estimate Drug-Drug Interaction and Food Effect
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Prediction of Plasma, Tissue and in vitro Cell Exposure of CS4 Chemicals Using IVIVE-PBPK and Biokinetic Models
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Development of a Mechanistic Model for the PBP/TK Based Prediction of Tissue Exposure Following Inhalation Exposure
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Application of PBPK modelling for prediction of tacrolimus exposure in CYP3A combined genotype groups (CYP3A4*22 and/or CYP3A5*3) and a renal transplant population
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In Vitro to In Vivo Extrapolation of Valproic Acid Hepatotoxicity: a Biokinetic and Physiologically Based Toxicokinetic Informed Approach
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Iterative Development of a Physiologically Based Pharmacokinetic Model for Valproic Acid and Reverse Translation of In Vitro Toxicity Data
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Iterative Development and Performance Verification of In Vitro Biokinetic Models
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Lysosomes- falling into a trap of our own making?
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Physiologically-Based Pharmacokinetic Modelling of Cyclosporine A in Rat
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USE OF A PBPK APPROACH TO ASSESS THE RISK OF DRUG INTERACTIONS IN DIABETIC PATIENTS ON POLYPHARMACY TREATMENT REGIMENS
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