In vivo indices of enzyme activity-the effect of renal impairment on the assessment of CYP2D6 activity.

Urinary drug metabolite ratios and urinary recoveries of metabolites, have been used to assess specific enzyme activity non-invasively in vivo. These indices are potentially confounded by the effect of renal function. A recent study of the effects of renal impairment has found discrepancies between different indices used to mark CYP2D6 activity based on sparteine and […]

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