Bioavailability of intranasal vs. rectal diazepam

There remains an unmet medical need in the out-of-hospital management of seizure emergencies because older children and adults often refuse treatment with rectal gel due to social objections. We have previously reported that intranasal diazepam (DZP) administration is feasible, with maximum plasma concentrations (Cmax) and time to maximum concentration (Tmax) that are comparable to rectal DZP; but tolerability was poor. In […]

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