Geoffrey Tucker – Certara

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The Absorption Kinetics of Ketoconazole Plays a Major Role in Explaining the Reported Variability in the Level of Interaction with Midazolam: Interplay Between Formulation and Inhibition of Gut Wall and Liver Metabolism

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Incorporation of an Electrochemical Driving Force for the Renal Transport of Metformin by OCT in a Physiologically-based Pharmacokinetic Model of the Interaction between Metformin and Cimetidine

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Metformin and Cimetidine: Physiologically-based Pharmacokinetic Modeling to Investigate Transporter Mediated Drug–drug Interactions

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Cytochrome P450 Turnover: Regulation of Synthesis and Degradation, Methods for Determining Rates, and Implications for the Prediction of Drug Interactions

In vivo enzyme levels are governed by the rates of de novo enzyme synthesis and degradation. A current lack of consensus on values of the in vivo turnover half-lives of human cytochrome P450 (CYP) enzymes places a significant limitation on the accurate prediction of changes in drug concentration-time profiles associated with interactions involving enzyme induction […]

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Prediction of time-dependent CYP3A4-mediated in vivo drug-drug interactions from in vitro data using biological information on enzyme turnover implemented within a physiologically-based model

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The Effect of P-glycoprotein (MDR1/ABCB1) on Human Gut Wall Absorption Depends on Physicochemical Characteristics of the Drug and Dosage Formulation: Simulation of “fa” for Digoxin, Quinidine and Talinolol

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Comparison of the “well-stirred” gut and the “Q_Gut” models for predicting intestinal first-pass metabolism

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Prediction of the In Vivo Behaviour of Modified Release Formulations of Metoprolol from In Vitro Dissolution Profiles Using the ADAM Model (Simcyp^® V8)

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Impact of Variability in Estimates of Drug Diffusion Coefficient on the Prediction of Fraction Absorbed from the Gut (fa) Using the ADAM Model (Simcyp v7.1)

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The Impact of Dose-Staggering on the Inhibitory Effect of Ketoconazole on Midazolam Clearance, and Its Prediction Using Physiologically-based Pharmacokinetic Modeling

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The Impact of Ketoconazole (KTZ) Dosage Regimen on Midazolam Clearance and Its Prediction Using PBPK Modeling

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In vitro – in vivo extrapolation of the clearance of drugs by glucuronidation: Scaling factors for recombinant UGT1A1 data

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CYP2C8 is a Previously Unreported Important Contributor to Olanzapine Oxidative Metabolism

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Prediction of the Increased Exposure to Drugs in Liver Cirrhosis: A Systems Biology Approach Integrating Prior Information on Disease with In Vitro In Vitro Data on Drug Disposition

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Mechanistic Models of Human Pharmacokinetics to Predict the Effects of Liver Cirrhosis on the Clearance of Nine Drugs

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A Novel Physiologically-based Mechanistic Model for Predicting Oral Drug Absorption: The Advanced Dissolution, Absorption, and Metabolism (ADAM) Model

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Bias in Estimates of Metabolic Constants When Applying the Michaelis-Menten Equation to Drugs Exhibiting Atypical Enzyme Kinetics

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A Critical Evaluation of the Experimental Design in Reports of Mechanism Based Inhibition (MBI) Studies and the Assessment of Their Implication for In Vitro-In Vivo Extrapolation (IVIVE)

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Prediction of the Oral Clearance of Midazolam Using In Vitro Data from Recombinantly Expressed Enzymes and Inter System Extrapolation Factors

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A Meta-analysis of CYP3A4 Abundance in Human Liver: Use of Different Standards Contributes to Apparent Heterogeneity in Reported Values

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