Precision Dosing Using PBPK Modeling

Devendra Pade

With the discovery of newer drugs, the “one-size-fits-all” approach towards therapy is becoming a thing of the past. The new paradigm of precision medicine aims at delivering the right treatment at the right time to the right patients. An integral part of precision medicine is administration of a precise dose, which is a critical step […]

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Topics: PBPK Modeling & Simulation

Precision Dosing Using PBPK Modeling

Precision dosing― the right dose, for the right patient, at the right time― is crucial to providing patients with the most efficacious medications with minimal probability of adverse events. One key step towards achieving the delivery of individualized dosing is testing potential dosing regimens in a patient’s ‘virtual twin.’ The other key step is to […]

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The Best Meds for Man’s Best Friend: PBPK Models for Animal Health

Devendra Pade

When people find out that you’re working to improve drug development for companion animals, you hear some colorful stories. The other day, one of my colleagues recounted to me the wild antics of Jinjer, her childhood dog. Jinjer was a 60 pound, fawn boxer, with a tiny stump of a tail, who loved everyone. This […]

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Topics: PBPK Modeling & Simulation

Evaluation of an In Silico PBPK Postbariatric Surgery Model through Simulating Oral Drug Bioavailability of Atorvastatin and Cyclosporine

An increasing prevalence of morbid obesity has led to dramatic increases in the number of bariatric surgeries performed. Altered gastrointestinal physiology following surgery can be associated with modified oral drug bioavailability (Foral). In the absence of clinical data, an indication of changes to Foral via systems pharmacology models would be of value in adjusting dose […]

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A Mechanistic Pharmacokinetic Model to Assess Modified Oral Drug Bioavailability Post Bariatric Surgery in Morbidly Obese Patients: Interplay Between CYP3A Gut Wall Metabolism, Permeability, and Dissolution

Due to the multi-factorial physiological implications of surgery, attempts to explain trends in oral bioavailability following bariatric surgery using singular attributes of drugs or simplified categorizations such as the biopharmaceutics classification system have been unsuccessful. So we have attempted to use mechanistic models to assess changes to bioavailability of model drugs. Pharmacokinetic post bariatric models were created for Roux-en-Y gastric bypass, biliopancreatic diversion with duodenal switch, […]

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