Optimal sampling times for a drug and its metabolite using SIMCYP® simulations as prior information.

Since 2007, it is mandatory for the pharmaceutical companies to submit a Pediatric Investigation Plan to the Pediatric Committee at the European Medicines Agency for any drug in development in adults, and it often leads to the need to conduct a pharmacokinetic study in children. Pharmacokinetic studies in children raise ethical and methodological issues. Because […]

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