Species differences in distribution and prediction of human Vss from preclinical data.

Prediction of human volume of distribution at steady state (Vss)before first administration of a new drug candidate to humans has become an important part of the drug development process. This study examines the assumptions behind interspecies scaling techniques used to predict human Vss. from preclinical data, namely the equivalency of Vss,u. and/or fut. across species. […]

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