Claudia Jomphe – Certara

Twenty four hour ammonia profiles and correlates of drug effect were examined in a phase 2 comparison of sodium phenylbutyrate (NaPBA) and glycerol phenylbutyrate (GPB or HPN-100), an investigational drug being developed for urea cycle disorders (UCDs). Study Design: Protocol HPN-100-005 involved open label fixed-sequence switch-over from the prescribed NaPBA dose to a PBA-equimolar GPB […]

Authors: Claudia Jomphe

Pharmacokinetic Analysis of β-Glucan After Administration of PGG-Glucan, a Novel Immunomodulator Being Developed for the Treatment of Non-Small Cell Lung Cancer

Ammonia control in children with urea cycle disorders (UCDs); Phase 2 comparison of sodium phenylbutyrate and glycerol phenylbutyrate.