Oral bioavailability is a key consideration in development of drug products, and the use of preclinical species in predicting bioavailability in human has long been debated. In order to clarify whether any correlation between human and animal bioavailability exist, an extensive analysis of the published literature data was conducted. Due to the complex nature of bioavailability calculations inclusion criteria were applied to ensure integrity of the data. A database of […]Read More
Will the 21st century go down in history as the “Chinese Century”? If the status of its pharmaceutical industry is a barometer for China’s global position, then the answer may be “yes.” The size of the Chinese pharmaceutical market is second only to the US. In 2014, it was worth $105 billion. By 2020, the Chinese market is expected to balloon to $200 billion and dominate Asia.
Big Pharma (e.g. GSK, AstraZeneca, Roche, Pfizer, Sanofi and Novartis) is capitalizing on this projected growth by setting up more and more Chinese research centers. Scientists at these centers are keen to learn how to apply modeling and simulation to their drug development programs.
One approach to modeling and simulation— physiologically-based pharmacokinetic (PBPK) modeling— has been used to optimize dosing and clinical trial designs. As PBPK models are getting more and more complex, scientists will require extensive training on both the theoretical and practical aspects of using tools such as the Simcyp Simulator, the gold standard. In this blog post, I will discuss my recent experience as a tutor for an educational workshop in Shanghai, China and reflect on their changing landscape for modeling and simulation.Read More