The Certara Blog

Author: Linzhong Li

Dr. Linzhong Li is a principal scientist and head of biologics at Certara. He currently leads the biologics science team, working on PBPK modeling on biologics in general, and bispecific antibodies, immunomodulatory antibodies, and antibody-drug conjugates, in particular.

Recent Posts

Mechanistic Modeling of Antibody Drug Conjugate Pharmacokinetics

Antibody Drug Conjugates (ADCs) are constructed by attaching a small molecule drug to an antibody via a linker. The antibody selectively targets tumor cells and releases the cytotoxic drug within the cells to kill cancerous cells while sparing healthy tissue. Although some ADCs have been approved, many unanswered questions remain, such as drug-drug interactions (DDIs) and […]

Read More
Learn More LinkedIn Twitter Facebook Email Subscribe to the Blog