The Certara Blog

Author: Angela Colbers

Dr. Angela Colbers is a biomedical scientist trained at Radboud University Medical Center in Nijmegen, the Netherlands, where she also obtained her PhD in the field of Clinical Pharmacology. Since 1995, she has been involved in clinical trial management, analysis, and reporting. She worked for a pharmaceutical company and contract research organizations. Since 2008, she has worked as a researcher at the department of Pharmacy of the Radboud University Medical Center, which has taken the initiative to set up a network of hospitals investigating pharmacokinetics in pregnancy in Europe. Dr. Colbers is project coordinator of a protocol entitled “Study on Pharmacokinetics of newly developed ANtiretroviral agents in HIV-infected pregNAnt women (PANNA)”. In addition, she teaches and advises PhDs and other students on developing and executing clinical trials, and she supports senior scientists with their research.

Recent Posts

Using PBPK Models to Optimize Anti-HIV Drug Dosing in Pregnant Women

Antiretroviral drugs are a critical tool in preventing mother-to-child transmission of HIV. Yet, antiviral treatment options for pregnant women lag behind the “non-pregnant” population. In this blog post, I’ll discuss the reasons for this lag and how physiologically-based pharmacokinetic (PBPK) models can simulate PK during pregnancy and thus help optimize dosing for this special population. […]

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