Certara at ACoP

Certara Poster Contributions to ASCPT

These posters’ abstracts were first published in the Clinical Pharmacology & Therapeutics March 2019 Supplement.

Thursday, March 14

5:00 pm – 6:30 pm

PII-018: Exposure-Response Analyses to Support Dose Justification of DS-8201A, A HER2-Targeting Antibody-Drug Conjugate, in HER2-Positive Breast Cancer Patients

Russ Wada, Helen Kastrissios (contributing authors)

PII-019: Population Pharmacokinetic Analysis of DS-8201a, A HER2-Targeting Antibody-Drug Conjugate, in Patients with HER2-Positive Breast Cancer or Other Solid Tumors

Yuan Xiong, Russ Wada (contributing authors)

PII-040: Simulating the Impact of the Interplay Between CYP2C19 Polymorphisms and Ethnicity on Response to Clopidogrel, Using PBPK-PD Models

Manoranjenni Chetty, Khaled Abdujalil

 

Friday, March 15
11:30 am – 1:00 pm

PIII-011: Relationship of Ivosidenib Plasma Concentration to Heart Rate-Corrected QT Interval in Patients with IDH1-Mutant Advanced Hematologic Malignancies

Bill Poland (contributing author)

PIII-012: Exposure-Response Analysis of Ivosidenib in Patients with IDH1-Mutant Relapsed or Refractory Acute Myeloid Leukemia

Huub Jan Kleijn (contributing author)

PIII-041: Physiologically-Based Pharmacokinetic Model-Based Assessments of CYP3A Expression Using Tacrolimus Pharmacokinetic Data Observed in Adult Obese and Pediatric Renal Transplant Patients

Trevor Johnson (contributing author)

PIII-067: Evaluation of Maternal Drug Exposure Following Administration of Dexamethasone and Betamethasone During Pregnancy Using Physiologically-Based Pharmacokinetic Modeling

Alice Ke

PIII-077: Validation of the Pharmacokinetic/Pharmacodynamic Model Used for Dose Selection of Andexanet Alfa for Reversal of Anticoagulation

Yuan Xiong, Mark Lovern (contributing authors)

PIII-087: Physiologically-Based Pharmacokinetic Modeling to Characterize Acetaminophen Target Attainment and Hepatotoxicity in Non-Pregnant and Pregnant Women

Marc Pfister (contributing author)

PIII-094: Development of a Physiologically-Based Pharmacokinetic Model for Topical Lidocaine in Order to Predict Systemic Absorption in Healthy Volunteers, Geriatrics, and Pediatrics

Nikunjkumar Patel, Farzaneh Salem, Sebastian Polak

PIII-116: Model Informed Quantification of the Feed-Forward Stimulation of Growth Hormone Secretion in Humans

Piet van der Graaf (contributing author)

PIII-117: Improving Clinical Translation of Neuroblastoma Treatment Effects by Integration of Preclinical Experimental Innovation and Computational Modeling

Piet van der Graaf (contributing author)

PIII-118: Population Pharmacokinetics of TAK-659, An Investigational Dual Inhibitor of SYK and FLT-3, in Patients with Hematologic Malignancies or Solid Tumors

Yuan Xiong, Paul Matthias Diderichsen (contributing authors)