Antiviral drug development presents a unique set of challenges. First, viruses are constantly mutating, and drug-resistant viruses emerge easily. Therefore, combination therapies are typically required to maintain a sustained virologic response. In addition, successful treatment requires high medication adherence, which is often a challenge for patients with chronic viral infections such as hepatitis or HIV. […]
Watch this webinar to learn how to use simulation to anticipate risks and preview the range of possible trial results before millions of R&D dollars are spent exposing subjects to experimental therapies.
A Product-profile-driven Clinical Utility Index (CUI) Analysis to Balance Benefits and Risks for Dose Selection in Oncology
Population Modeling of Modified Risk Tobacco Products Accounting for Smoking Reduction and Gradual Transitions of Relative Risk
Implementation of a Highly Nonlinear, Multi-scaled and Long-term HIV Dynamic Model with Treatment Interruptions and Non-static BQL Data for Population Analysis
The Oxford Dictionaries 2014 Word of the Year is “vape” – to inhale and exhale the vapor produced by an electronic cigarette (also known as e-cigarette or e-cig) or similar device. This choice reflects the meteoric rise in e-cig popularity. E-cigs, which deliver nicotine without carcinogenic tar, hold the promise to save the lives of […]