Over the last 15 years, the importance of drug transporters has become paramount for understanding drug absorption, distribution into tissues, and in particular, drug-drug interactions (DDIs). In vitro-in vivo extrapolation (IVIVE) is an approach to link in vitro systems to the human in vivo situation using algorithms and physiologically-based scaling factors. In this blog, I […]
Read MoreBeam Me Up, Scotty! Probing the Mechanisms of Transporter-mediated Drug Disposition
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PBPK Modeling & Simulation