Age Related Changes in Fractional Elimination Pathways for Drugs: Assessing the Impact of Variable Ontogeny on Metabolic Drug-drug Interactions

The magnitude of any metabolic drug-drug interactions (DDIs) depends on fractional importance of inhibited pathway which may not necessarily be the same in young children when compared to adults. The ontogeny pattern of cytochrome P450 (CYP) enzymes (CYPs 1A2, 2B6, 2C8, 2C9, 2C18/19, 2D6, 2E1, 3A4) and renal function were analyzed systematically. Bootstrap methodology was … Continued

Certara and Veristat Expand Clinical Trial Service Offerings with New Partnership

Collaboration offers clients more streamlined and efficient approach to clinical trial planning ST. LOUIS, MO and HOLLISTON, MA – May 14, 2013 – Certara™, a leading provider of software and scientific consulting services to improve productivity and decision-making from drug discovery through clinical development, and Veristat, LLC., a leading full service clinical research organization, today … Continued

The Future of the Pharmaceutical Sciences and Graduate Education: Recommendations from the AACP Graduate Education Special Interest Group

Despite pharma’s recent sea change in approach to drug discovery and development, U.S. pharmaceutical sciences graduate programs are currently maintaining traditional methods for master’s and doctoral student education. The literature on graduate education in the biomedical sciences has long been advocating educating students to hone soft skills like communication and teamwork, in addition to maintaining … Continued

Time to Tumor Growth Helps Predict Survival Benefit of Bevacizumab for Patients

Paper published in the Journal of Clinical Oncology proposes new mathematical modeling approach to analyzing oncology clinical trial data ST. LOUIS, MO – May 8, 2013 – Certara™, a leading provider of software and scientific consulting services to improve productivity and decision-making from drug discovery through drug development, announced that its Pharsight Consulting Services has … Continued