PK/PD Modeling & Simulation

Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body

Nathan Teuscher

When I first began learning about pharmacokinetics, I was often confused by the mean residence time (MRT) parameter. I wasn’t really sure what it meant, how to interpret the value, and why it would ever be important. After many years of working with pharmacokinetic analysis, I still do not use MRT very often, but I […]

Read More
Topics: PK/PD Modeling & Simulation

What is a Loading Dose?

Nathan Teuscher

Drug therapy in chronic disease situations requires systemic drug levels to reach target steady-state levels for maximum safety and efficacy. The time it takes for a drug to reach steady-state is a function of the elimination half-life of the drug. The following table illustrates how long it will take to achieve steady-state relative to the […]

Read More
Topics: PK/PD Modeling & Simulation

The Superposition Principle

Nathan Teuscher

The superposition principle has nothing to do with a super-hero; however, you might be perceived as a hero if you can explain the principle to others. The superposition principle is a mathematical concept that helps us analyze concentration-time data. While it may seem complicated, it is actually nothing more than addition! The superposition principle states […]

Read More
Topics: PK/PD Modeling & Simulation
Learn More LinkedIn Twitter Facebook Email