PK/PD Modeling & Simulation

What Can We Learn from a Human Mass Balance Study?

Nathan Teuscher

Mass balance studies are also called “C-14 studies” or “Absorption, Metabolism, and Excretion (AME) studies”. It is important to understand what you are trying to learn from the experiment. The primary objectives of a mass balance study are generally: To determine the mass balance of drug-related material following dose administration To determine the ratio of […]

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Topics: PK/PD Modeling & Simulation

Accumulation: What It Means and How to Calculate It

Nathan Teuscher

A reader, Michael, asked me to discuss the concept of accumulation. This term is used frequently in both the nonclinical and clinical setting. Some people use the word with fear, while others explain it in complicated terms. Accumulation represents the relationship between the dosing interval and the rate of elimination for the drug. When the […]

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Topics: PK/PD Modeling & Simulation

Bioavailability

Nathan Teuscher

The term bioavailability is used very frequently in pharmacokinetic discussions. Often it is misused and complicated by those who don’t understand its meaning. Bioavailability simply means the fraction of administered drug that reached the systemic circulation (blood). It can range from 0% (no drug) to 100% (all of the administered drug). Absolute vs Relative The […]

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Topics: PK/PD Modeling & Simulation
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