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Featured Articles + Publications


Dealing with excess of zeros in the statistical analysis of magnetic resonance imaging lesion count

This paper compares the performances of Poisson, zeroinflated poisson (ZIP), negative binomial (NB), and zero-inflated NB (ZINB) mixed-effects regression models in fitting lesion count data in a clinical trial evaluating the efficacy and safety of fingolimod in comparison with placebo, in MS...

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Featured Presentations


Should We Tolerate the Maximally Tolerated Dose for Targeted Anti-Cancer Agents?

This presentation was given by Rene Bruno, Managing Director, Europe, Certara, at the Society for Clinical Pharmacology and Therapeutics (ASCPT) Annual Meeting in March, 2012.

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Logical Data Relationships: Solving Informatics Problems for Translational Research

This presentation was given by David R. Lowis, D. Phil., Senior Director of Product Management, Certara, at the Global Discovery & Development Innovation Forum (GDDIF) in March, 2012, where he discussed the need for consolidation of data from multiple disciplines, providing a more holistic view of the patient, disease, treatment and underlying science, to support translational science initiatives. 

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Featured Webcasts


Modeling and Simulation in Pediatric Drug Development

This recorded webinar presents general principles of modeling and simulation to optimize pediatric trial design and support dosing rationale to ensure adequate safety and efficacy of treatments intended for pediatric use. Both “top-down” and “bottom-up” approaches are discussed as part of a modeling framework to better understand and predict complex drug and system dynamics. The session includes case examples of these synergistic approaches in a shared clinical indication.

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Featured White Papers / Application Notes


D360 Case Study-Streamlined, Self-Service Access to Biology and Chemistry Data

In this case study, we review the challenges scientists at a small biotech company consistently experienced when attempting to access and merge their chemistry and biology data, which were stored in different systems, and after deploying Certara's D360, were able to free the time of scientists who were formerly charged with data extraction duties to best make use of their scientific capabilities.

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Modeling and Simulation in Pediatric Drug Development
(recorded webinar) Modeling and simulation to optimize pediatric trial design and support dosing rationale to ensure adequate safety and efficacy of treatments View recorded webcast

Case Study: Cross Study Analysis of Safety Data Top 10 Pharma Company deployed D360 to enable cross study analysis of their preclinical safety data. Learn More

Pharmacokinetic mAb-mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts Examines the effects of an anti-vascular endothelial growth factor (anti-VEGF) antibody on the plasma, tissue, and tumor disposition... Learn More

Pharmacokinetic and Pharmacodynamic Data Analysis, Concepts and Applications, 3rd ed.

Gabrielsson J,
Weiner D.
Stockholm, Sweden: Swedish Pharmaceutical Press; 2001. ISBN 91-8627-492-9.