Certara offers predictive science and informatics solutions that enable cross-disciplinary and translational approaches to drug development.
The Simcyp Paediatric Simulator allows pharmacokinetic behaviour to be modelled in neonates, infants and children. This provides valuable information relevant to first-time dosing decisions and the design of paediatric clinical studies.
The Simulator includes a full physiologically-based pharmacokinetic (PBPK) model together with extensive libraries on demographics, developmental physiology and the ontogeny of drug elimination pathways. It allows population variability in pharmacokinetics to be simulated over any age range and potential drug-drug interactions to be quantified. Predictions can be made either from in vitro data or from adult in vivo values by retrograde modelling.
Simcyp Paediatric is a module within the Simcyp Population-based Simulator which is licensed to members of the Simcyp Consortium of leading pharmaceutical and biotechnology companies.